David Antcliffe is a Clinical Senior Lecturer at Imperial College and an Honorary Consultant in Critical Care at Charing Cross Hospital.

He obtained his degree in medicine in 2003 from University College London and pursued post-graduate training in Acute and Intensive Care Medicine across London. Between 2011 and 2015 he completed a PhD at Imperial College using metabolic profiling to aid in the diagnosis of pneumonia in patients requiring critical care funded by the Imperial College BRC and the Intensive Care Foundation.

After obtaining a dual CCT in Acute and Intensive Care Medicine in 2016 he returned to Imperial College to continue pursuing his academic interests in phenotyping critical illness.

His current research interests involve using a range of profiling techniques, including metabonomic, transcriptomic and inflammatory profiling, to identify sub-phenotypes in sepsis that could predict a patient's responsiveness to specific therapeutic strategies and lead to a personalised approach to sepsis care. This approach has lead to the finding that stratifying patients with septic shock based on the way in which their genes are expressed (sepsis response signature (SRS) transcriptomic endotypes) identified groups who respond differently to corticosteroids in this condition. Ongoing work aims to translate this finding to the bedside to use point of care tests to identify patients who are most likely to benefit from these interventions.